NCBI Summary:
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
General function
Intracellular signaling cascade
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Steroid metabolism
Comment
miR-130a-3p regulates steroid hormone synthesis in goat ovarian granulosa cells by targeting the PMEPA1 gene.
Theriogenology. 2021 Feb 19;165:92-98. [Epub ahead of print]
PMID: 3364774