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HPMR

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GDNF family receptor alpha like OKDB#: 5495
 Symbols: GFRAL Species: human
 Synonyms: GRAL, UNQ9356, C6orf144, bA360D14.1  Locus: 6p12.1 in Homo sapiens
HPMR


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General Comment GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Yang L et al. (2017) Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GDF15 binds specifically to GDNF family receptor α-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF15 stimulation. We also found that GDF15-mediated reductions in food intake and body weight of mice with obesity were abolished in GFRAL-knockout mice. We further found that GFRAL expression was limited to hindbrain neurons and not present in peripheral tissues, which suggests that GDF15-GFRAL-mediated regulation of food intake is by a central mechanism. Lastly, given that GDF15 did not increase energy expenditure in treated mice with obesity, the anti-obesity actions of the cytokine are likely driven primarily by a reduction in food intake.//////////////////

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
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Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Aug. 30, 2017, 2:22 p.m. by: system   email:
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last update: Aug. 30, 2017, 2:26 p.m. by: hsueh    email:



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