| LSM family member 14B | OKDB#: 5463 |
| Symbols: | LSM14B | Species: | human | ||
| Synonyms: | FT005, LSM13, FAM61B, RAP55B, C20orf40, bA11M20.3 | Locus: | 20q13.33 in Homo sapiens |
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| General Comment | ||||
| General function | RNA binding | |||
| Comment | ||||
| Cellular localization | ||||
| Comment | ||||
| Ovarian function | Oocyte maturation | |||
| Comment | RNA-associated protein LSM family member 14 controls oocyte meiotic maturation through regulating mRNA pools. Zhang T et al. (2017) LSM family member 14 (LSM14) belongs to the RNA-associated protein (RAP) family that is widely expressed in different species, and whose functions include associating and storing mRNAs. In the present study, we found that LSM14b was essential for oocyte meiotic maturation. Lack of LSM14b caused oocyte meiotic arrest at metaphase, and misalignment of chromosomes, as well as abnormal spindle assembly checkpoint (SAC) and maturation promoting factor (MPF) activation. Cyclin B1 and Cdc20 mRNAs, whose contents changed with LSM14b expression, were likely direct targets of LSM14b. We conclude that LSM14b, by functioning as a container of mRNAs, controls protein expression, and thus regulates the oocyte meiotic maturation process.////////////////// | |||
| Expression regulated by | ||||
| Comment | ||||
| Ovarian localization | Oocyte | |||
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| Follicle stages | ||||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | May 3, 2017, 12:49 p.m. | by: |
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| last update: | May 9, 2018, 2:18 p.m. | by: | hsueh email: |
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