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cullin 9 OKDB#: 5414
 Symbols: CUL9 Species: human
 Synonyms: cullin-9  Locus: 4 in Homo sapiens


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General Comment
General function
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Cellular localization
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Ovarian function
Comment Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin. Dai X et al. (2016) The Cullin9 gene encodes a putative E3 ligase that serves a wide variety of biological functions in mitosis, whereas its roles in meiosis have not yet clearly defined. Here, we report that Cullin9 accumulates on the spindle apparatus and colocalizes with the microtubule fibers during mouse oocyte meiotic maturation. Depletion of Cullin9 by morpholino microinjection results in a remarkably higher rate of disorganized spindles and misaligned chromosomes in oocytes, which is coupled with the impaired kinetochore-microtubule attachments. Resultantly, the incidence of aneuploid eggs significantly increases in Cullin9-depleted oocytes. Moreover, we show that Cullin9 controls Survivin's protein level during meiotic maturation, and thus regulates microtubule stability in oocytes. Thus, our study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via Survivin.//////////////////
Expression regulated by
Comment
Ovarian localization Oocyte
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Follicle stages
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Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: Nov. 8, 2016, 4:14 p.m. by: system   email:
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last update: Nov. 8, 2016, 4:14 p.m. by: hsueh    email:



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