NCBI Summary:
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
General function
Chromosome organization, Cell cycle regulation
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Cellular localization
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Ovarian function
Early embryo development
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Expression regulated by
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Ovarian localization
Oocyte
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Nek11 regulates asymmetric cell division during mouse oocyte meiotic maturation. Guo L et al. (2016) Nek11 is a member of the never in mitosis-gene A (NIMA)-related kinases. Activated NEK11 is associated with G1/S or G2/M arrest in somatic cells, but its function in meiosis is unknown. In this research, the expression, localization and functions of NEK11 in the mouse oocyte meiotic maturation were examined. Western blotting showed that Nek11S was the major Nek11 protein in mouse oocyte. MYC-tagged Nek11 mRNA microinjection and immunofluorescent staining showed that NEK11 was localized to the meiotic spindles at MI and MII stage. Knockdown of Nek11 by microinjection of siRNA did not affect germinal vesicle breakdown (GVBD) and the first polar body extrusion, but caused formation of 2-cell-like eggs. These results demonstrate that Nek11 regulates asymmetric cell division during oocyte meiotic maturation.//////////////////