| insulin like growth factor binding protein 4 | OKDB#: 5340 |
| Symbols: | IGFBP4 | Species: | human | ||
| Synonyms: | BP-4, IBP4, IGFBP-4, HT29-IGFBP | Locus: | 17q21.2 in Homo sapiens |
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| General Comment | NCBI Summary: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] | ||||
| General function | Extracellular binding protein | ||||
| Comment | |||||
| Cellular localization | Secreted | ||||
| Comment | Serum and follicular fluid levels of IGF-II, IGF-binding protein-4 and pregnancy-associated plasma protein-A in controlled ovarian hyperstimulation cycle between polycystic ovarian syndrome (PCOS) and non-PCOS women. Zhong G et al. (2011) To investigate the difference of serum and follicular expression patterns for IGFα, IGFBP4 and PAPP-A in COH cycle between PCOS and non-PCOS women. COH was performed for total 30 sterile women (20 with PCOS and 10 with normal ovarian function). The serum and follicular fluid (FF)from dominant follicles levels of IGFα, IGFBP4 and PAPP-A before COH, day of hCG, and were measured using an ELISA. The PCOS women had significantly higher day 3 serum PAPP-A, day of hCG serum IGFBP-4, and ff IGF-II levels compared to the normoovulatory subjects. Serum levels of IGF-II and IGFBP-4 in PCOS women had increased after gonadotropins stimulation, and yet PAPP-A was decreased. Within the PCOS women, day of hCG serum IGFBP-4 was strongly correlated with BMI (r=0.777; P=0.000), day of hCG IGF II (r= -0.573, p=0.008), ff IGF II (r= -0.573, p=0.008) and ff PAPP-A (r= -0.461, p=0.041) was inversely related to diameter >16 mm follicle number and day 3 PAPP-A correlated to diameter > 16 mm follicle number (r=0.474; p=0.035). Ovarian IGF system on the gonadotropin response to differences in the PCOS and non-PCOS women in COH cycle, and may indicate a inordinate IGF system that might disturb folliculogenesis in PCOS women.////////////////// | ||||
| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
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| Follicle stages | |||||
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| Phenotypes |
PCO (polycystic ovarian syndrome) |
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 26, 2016, 4:17 p.m. | by: |
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| last update: | Jan. 26, 2016, 4:17 p.m. | by: | hsueh email: |
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