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Ovarian Kaleidoscope Database (OKdb)

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vascular endothelial growth factor B OKDB#: 5260
 Symbols: VEGFB Species: human
 Synonyms: VRF, VEGFL  Locus: 11q13 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment NCBI Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
General function Ligand, Growth factor
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment Serum vascular endothelial growth factor-B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Cheng F et al. (2015) To determine serum vascular endothelial growth factor B levels in polycystic ovary syndrome, their association with insulin resistance and β-cell dysfunction, and the effect of metformin on serum vascular endothelial growth factor B levels. A cross-sectional, interventional study. We recruited 103 women with polycystic ovary syndrome and 96 age-matched healthy controls. Serum vascular endothelial growth factor B levels were determined in all participants, and 44 polycystic ovary syndrome patients randomly received metformin. We measured vascular endothelial growth factor B levels in healthy controls and women with polycystic ovary syndrome before and after metformin treatment. Women with polycystic ovary syndrome had higher serum vascular endothelial growth factor B levels, which decreased with metformin treatment. In the lean and overweight/obese groups, patients with polycystic ovary syndrome had higher plasma vascular endothelial growth factor B levels than did healthy controls (P < 0.05). Vascular endothelial growth factor B levels were correlated with body mass index, body fat percentage, M values, homeostasis model assessment of insulin resistance, and β-cell function indices. A multiple linear regression analysis showed that vascular endothelial growth factor B level was associated with M values after adjusting for age, body mass index, serum sex hormones, and serum lipids in women with polycystic ovary syndrome. Serum vascular endothelial growth factor B is significantly higher in women with polycystic ovary syndrome and is closely and positively related to insulin resistance. Metformin treatment reduces vascular endothelial growth factor B levels and ameliorates insulin resistance. This article is protected by copyright. All rights reserved.//////////////////
Follicle stages
Comment
Phenotypes PCO (polycystic ovarian syndrome)
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
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created: Sept. 30, 2015, 12:40 p.m. by: system   email:
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last update: Sept. 30, 2015, 12:41 p.m. by: hsueh    email:



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