NCBI Summary:
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
General function
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Oocyte maturation
Comment
Sweet action: The dynamics of O-GlcNAcylation during meiosis in mouse oocytes. Slawson C et al. (2015) Post-translational modifications regulate mitosis and meiosis. For example, O-GlcNAcylation -the addition of a single N acetyl-glucosamine (O-GlcNAc) to serine or threonine residues- is required for mitotic spindle formation and chromosome segregation; here we show that O-GlcNAcylation occurs in mouse oocytes during meiosis. O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which respectively adds and removes this modification, are expressed and active during meiosis. This article is protected by copyright. All rights reserved.//////////////////