| ectodysplasin A | OKDB#: 5197 |
| Symbols: | EDA | Species: | human | ||
| Synonyms: | ED1, HED, EDA1, EDA2, HED1, ODT1, XHED, ECTD1, XLHED, ED1-A1, ED1-A2, EDA-A1, EDA-A2, STHAGX1 | Locus: | Xq12-q13.1 in Homo sapiens |
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Entrez Gene
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| General Comment |
Involved in stem cell competition (Thomas Zwaka)/////Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen. Dejosez M et al. (2013) Ensuring cooperation among formerly autonomous cells has been a central challenge in the evolution of multicellular organisms. One solution is monoclonality, but this option still leaves room for exploitative behavior, as it does not eliminate genetic and epigenetic variability. We therefore hypothesized that embryonic development must be protected by robust regulatory mechanisms that prevent aberrant clones from superseding wild-type cells. Using a genome-wide screen in murine induced pluripotent stem cells, we identified a network of genes (centered on p53, topoisomerase 1, and olfactory receptors) whose down-regulation caused the cells to replace wild-type cells in vitro and in the mouse embryo--without perturbing normal development. These genes thus appear to fulfill an unexpected role in fostering cell cooperation.//////////////////
NCBI Summary: The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| General function | Ligand, Growth factor | ||||
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| Cellular localization | Secreted, Plasma membrane | ||||
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| Ovarian function | Early embryo development | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 5, 2015, 12:30 p.m. | by: |
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| last update: | Aug. 6, 2015, 2:43 p.m. | by: | hsueh email: |
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