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meiotic kinetochore factor OKDB#: 5123
 Symbols: MEIKIN Species: human
 Synonyms:  Locus: 5q31.1 in Homo sapiens


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General Comment
General function Chromosome organization
Comment
Cellular localization Nuclear
Comment
Ovarian function Oocyte maturation , Germinal vesicle breakdown
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages Antral, Preovulatory
Comment
Phenotypes
Mutations 1 mutations

Species: mouse
Mutation name:
type: null mutation
fertility: infertile - ovarian defect
Comment: Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Kim J et al. (2015) The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules emanating from the same spindle pole (mono-orientation) and centromeric cohesion mediated by cohesin is protected in the following anaphase. Although meiotic kinetochore factors have been identified only in budding and fission yeasts, these molecules and their functions are thought to have diverged earlier. Therefore, a conserved mechanism for meiotic kinetochore regulation remains elusive. Here we have identified in mouse a meiosis-specific kinetochore factor that we termed MEIKIN, which functions in meiosis I but not in meiosis II or mitosis. MEIKIN plays a crucial role in both mono-orientation and centromeric cohesion protection, partly by stabilizing the localization of the cohesin protector shugoshin. These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner. Our integrative analysis indicates that the long-awaited key regulator of meiotic kinetochore function is Meikin, which is conserved from yeasts to humans.//////////////////

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created: Feb. 2, 2015, 4:22 a.m. by: system   email:
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last update: Feb. 2, 2015, 4:25 a.m. by: hsueh    email:



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