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General Comment |
RSPOLGR4 functions via IQGAP1 to potentiate Wnt signaling
Kendra S. Carmon, Xing Gong, Jing Yi, Anthony Thomas, and Qingyun Liu1
Author Affiliations
Edited by Roeland Nusse, Stanford University School of Medicine, Stanford, CA, and approved February 20, 2014 (received for review December 11, 2013)
AbstractAuthors & InfoSIMetricsPDFPDF + SI
Significance
R-spondins (RSPOs) and LGR4 emerged as a major ligandreceptor system in the regulation of Wnt signaling as manifested in their pleotropic roles in development and survival of adult stem cells. The mechanism of how RSPOLGR4 interacts with the Wnt signaling system remains poorly understood. In this work, we describe the identification of IQGAP1 as the first intracellular signaling partner of RSPOLGR4 and the delineation of IQGAP1s roles and mechanism in mediating RSPOLGR4-induced potentiation of Wnt signaling. We also elucidate the relationship between the RSPOLGR4IQGAP1 pathway and the function of RSPOLGR4 in inhibiting RNF43/ZNRF3. The findings uncovered a unique mechanism of RSPOLGR4 signaling and provide a mechanistic basis for the pleiotropic functions of RSPOLGR4 signaling in normal and pathological processes.
NCBI Summary:
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
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