| Dab, reelin signal transducer, homolog 1 (Drosophila) | OKDB#: 4984 |
| Symbols: | DAB1 | Species: | human | ||
| Synonyms: | Locus: |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | |||||
| General function | Intracellular signaling cascade | ||||
| Comment | |||||
| Cellular localization | Cytoplasmic | ||||
| Comment | |||||
| Ovarian function | Antral follicle growth | ||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Granulosa | ||||
| Comment | Signalling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle. Eresheim C 2014 et al. Chicken oocytes develop in follicles and reach an enormous size due to massive uptake of yolk precursors such as very low density lipoprotein and vitellogenin. Oocyte growth is supported by theca cells and granulosa cells which establish dynamic and highly organized cell layers surrounding the oocyte. Signalling processes orchestrating the development of these layered structures are largely unknown. Here we demonstrate that the Reelin pathway which determines the development of layered neuronal structures in the brain is also active in chicken follicles. Reelin, which is expressed in theca cells triggers a signal in granulosa cells via apolipoprotein E receptor 2 and very low density lipoprotein receptor resulting in the phosphorylation of disabled-1 and consecutive activation of the phosphatidylinositol-3-kinase/Akt pathway. This signalling pathway supports proliferation of differentiated granulosa cells to keep up with the demand of cells to cover the rapidly increasing surface of the giant germ cell. ///////////////////////// | ||||
| Follicle stages | |||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
|
| created: | March 4, 2014, 12:54 p.m. | by: |
hsueh email:
home page: |
| last update: | March 4, 2014, 12:55 p.m. | by: | hsueh email: |
Click here to return to gene search form