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Ovarian Kaleidoscope Database (OKdb)

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asunder spermatogenesis regulator OKDB#: 4951
 Symbols: ASUN Species: human
 Synonyms: GCT1, NET48, Mat89Bb, SPATA30, C12orf11,  Locus: 12p11.23 in Homo sapiens


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General Comment
General function
Comment
Cellular localization
Comment
Ovarian function Oogenesis
Comment asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesis. Sitaram P 2013 et al. We previously showed that asunder (asun) is a critical regulator of dynein localization during Drosophila spermatogenesis. Because the expression of asun is much higher in Drosophila ovaries and early embryos than in testes, we herein sought to determine whether ASUN plays roles in oogenesis and/or embryogenesis. We characterized the female germline phenotypes of flies homozygous for a null allele of asun (asun(d93)). We find that asun(d93) females lay very few eggs and contain smaller ovaries with a highly disorganized arrangement of ovarioles in comparison to wild-type females. asun(d93) ovaries also contain a significant number of egg chambers with structural defects. A majority of the eggs laid by asun(d93) females are ventralized to varying degrees, from mild to severe; this ventralization phenotype may be secondary to defective localization of gurken transcripts, a dynein-regulated step, within asun(d93) oocytes. We find that dynein localization is aberrant in asun(d93) oocytes, indicating that ASUN is required for this process in both male and female germ cells. In addition to the loss of gurken mRNA localization, asun(d93) ovaries exhibit defects in other dynein-mediated processes such as migration of nurse cell centrosomes into the oocyte during the early mitotic divisions, maintenance of the oocyte nucleus in the anterior-dorsal region of the oocyte in late-stage egg chambers, and coupling between the oocyte nucleus and centrosomes. Taken together, our data indicate that asun is a critical regulator of dynein localization and dynein-mediated processes during Drosophila oogenesis. /////////////////////////
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: Dec. 19, 2013, 11:41 a.m. by: hsueh   email:
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last update: Dec. 19, 2013, 11:42 a.m. by: hsueh    email:



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