| Peptidyl-prolyl Isomerase B | OKDB#: 480 |
| Symbols: | PPIB | Species: | rat | ||
| Synonyms: | CYCLOPHILIN B, CYPB| | Locus: |
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| General Comment |
The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high
affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation
of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is
blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.
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| General function | Enzyme, Isomerase | ||||
| Comment | |||||
| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | |||||
| Comment | This gene was found in a rat ovarian cDNA library (Unigene) | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 31, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Aug. 14, 2001, 9:05 a.m. | by: | Hsueh email: |
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