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peptidase D OKDB#: 4793
 Symbols: PEPD Species: human
 Synonyms: PROLIDASE  Locus: 19q13.11 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment NCBI Summary: This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
General function Enzyme, Peptidase/Protease
Comment
Cellular localization
Comment candidate123
Ovarian function
Comment Increased Prolidase Activity and Oxidative Stress in PCOS. Hilali N et al. AIM: Matrix metalloproteinases (MMPs) have been considered to have a role in various pathological processes including inflammatory response, cardiovascular disease, and recently also in ovarian dysfunction. Since prolidase could be accepted as a matrix metalloproteinase, on the biochemical level, we aimed to evaluate serum prolidase activity and oxidative-antioxidative status in patients with polycystic ovary syndrome (PCOS) and healthy individuals. MATERIALS AND METHODS: Thirty-three PCOS patients and twenty-eight healthy nonhyperandrogenic women were studied. Levels of prolidase activity, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T) and prolactin (PRL) were calculated. RESULTS: Levels of prolidase activities, total oxidant status, oxidative stress index, LH, PRL, and T were significantly higher in PCOS group than in the control group. Total antioxidant status levels were lower in PCOS group than healthy group but it was not statistically significant. There was no significant difference between PCOS and control groups in term of FSH. CONCLUSION: Women with PCOS have increased serum prolidase activity, and oxidative stress. It might be hypothesized that elevated serum prolidase activity, and oxidative stress may be associated with increased cardiovascular risk in PCOS and/or menstrual irregularities associated with this syndrome. 2012 Blackwell Publishing Ltd.
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes PCO (polycystic ovarian syndrome)
Mutations 1 mutations

Species: human
Mutation name:
type: naturally occurring
fertility: subfertile
Comment: The role of rs267606943 polymorphism in the prolidase gene and plasma prolidase in polycystic ovary syndrome. Bhatnager R et al. (2018)//////////////////

Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Nov. 28, 2012, 10:45 a.m. by: hsueh   email:
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last update: March 21, 2020, 1:42 a.m. by: hsueh    email:



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