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RIKEN cDNA E330034G19 gene OKDB#: 4666
 Symbols: E330034G19Rik Species: human
 Synonyms: AA415275,  Locus: 14 in Homo sapiens


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General Comment
General function
Comment
Cellular localization
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Ovarian function Oocyte maturation
Comment
Expression regulated by
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Ovarian localization Oocyte
Comment Comparative proteomic analysis of proteins involved in oocyte meiotic maturation in mice. Cao S et al. After birth, oocytes stay at the diplotene stage in prophase of meiosis I. Meiosis resumes about one day before ovulation, and arrests in metaphase II (MII) after ovulation. The mature, MII oocytes are then ready for fertilization and to provide materials for early embryonic development. Proteomic characterization of oocytes can help identify proteins that are important for female meiotic maturation and early embryonic development. In this study, we compared the proteomic profiles between the germinal vesicle (GV) and MII mouse oocytes by two-dimensional electrophoresis; 95 differentially expressed protein spots corresponding to 63 proteins were identified. Many of these proteins are known to be essential for oocyte meiosis and early embryonic development, such as adenylosuccinate synthetase (ADSS), nucleoplasmin-2 (NPM2), and protein-arginine deiminase type-6 (PADI6). Of the 12 proteins that were identified and are highly-expressed in oocytes, a novel protein, E330034G19Rik, was found to be oocyte-specific. According to analysis by bioinformatics, it may regulate chromosome segregation during meiosis or cleavage. An in-depth study of these proteins will help us better understand the mechanisms of oocyte meiotic maturation, fertilization, and early embryogenesis. It will also help us understand the mechanisms of diseases that stem from abnormal oocyte maturation, such as polycystic ovary syndrome and premature ovary failure. Mol. Reprod. Dev. 2012 Wiley Periodicals, Inc.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: April 18, 2012, 1:50 p.m. by: hsueh   email:
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last update: April 18, 2012, 1:50 p.m. by: hsueh    email:



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