| WW and C2 domain containing 1 | OKDB#: 4564 |
| Symbols: | WWC1 | Species: | human | ||
| Synonyms: | KIBRA, HBEBP3, HBEBP36, FLJ10865, FLJ23369, KIAA0869, | Locus: | 5q34 in Homo sapiens |
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| General Comment |
This gene is upstream of Hippo signaling. In mammalian cells,
WWC1 restrains YAP1s activity through LATS1/2 kinases but not MST1/2 kinases (58, 59),
NCBI Summary: The Hippo pathway protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Oct. 13, 2011, 11:11 a.m. | by: |
hsueh email:
home page: |
| last update: | Oct. 22, 2013, 4:31 p.m. | by: | hsueh email: |
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