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HPMR

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von Willebrand factor C domain containing 2 OKDB#: 4528
 Symbols: VWC2 Species: human
 Synonyms: UNQ739, PSST739, MGC131845,  Locus: 7p12.2 in Homo sapiens


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General Comment NCBI Summary: This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.
General function Ligand
Comment
Cellular localization Secreted
Comment
Ovarian function Follicle development
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Identification and Regulation of Bone Morphogenetic Protein Antagonists Associated with Preantral Follicle Development in the Ovary. Fenwick MA et al. The TGF superfamily comprises several bone morphogenetic proteins (BMP) capable of exerting gonadotropin-independent effects on the development of small preantral follicles. In embryonic tissues, BMP concentration gradients, partly formed by antagonistic factors, are essential for establishing phenotypic fate. By examining the expression of candidate genes whose protein products are known to interact with BMP ligands, we set out to determine which antagonists would most likely contribute toward regulation of paracrine signaling during early follicle development. Juvenile mouse ovaries of 4, 8, 12, and 21 d of age enriched with follicles at successive developmental stages were used to assess changes in candidate gene transcripts by quantitative RT-PCR. Although some antagonists were found to be positively associated with the emergence of developing follicles (Nog, Htra1, Fst, Bmper, Vwc2), two (Sostdc1, Chrd) showed a corresponding reduction in expression. At each age, twisted gastrulation homolog 1 (Twsg1), Htra1, Nbl1, and Fst were consistently highly expressed and localization of these genes by in situ hybridization, and immunohistochemistry further highlighted a clear pattern of expression in granulosa cells of developing follicles. Moreover, with the exception of Nbl1, levels of these antagonists did not change in preantral follicles exposed to FSH in vitro, suggesting regulation by local factors. The presence of multiple antagonists in the juvenile ovary and their high level of expression in follicles imply the actions of certain growth factors are subject to local modulation and further highlights another important level of intraovarian regulation of follicle development.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Aug. 4, 2011, 2:53 p.m. by: hsueh   email:
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last update: Aug. 4, 2011, 2:55 p.m. by: hsueh    email:



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