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MON2 homolog (S. cerevisiae) OKDB#: 4494
 Symbols: MON2 Species: human
 Synonyms: KIAA1040, MGC35493,  Locus: 12q14.1 in Homo sapiens


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General Comment
General function
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Cellular localization
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Ovarian function Early embryo development
Comment Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. Tanaka T et al. Drosophila pole (germ) plasm contains germline and abdominal determinants. Its assembly begins with the localization and translation of oskar (osk) RNA at the oocyte posterior, to which the pole plasm must be restricted for proper embryonic development. Osk stimulates endocytosis, which in turn promotes actin remodeling to form long F-actin projections at the oocyte posterior pole. Although the endocytosis-coupled actin remodeling appears to be crucial for the pole plasm anchoring, the mechanism linking Osk-induced endocytic activity and actin remodeling is unknown. Here, we report that a Golgi-endosomal protein, Mon2, acts downstream of Osk to remodel cortical actin and to anchor the pole plasm. Mon2 interacts with two actin nucleators known to be involved in osk RNA localization in the oocyte, Cappuccino (Capu) and Spire (Spir), and promotes the accumulation of the small GTPase Rho1 at the oocyte posterior. We also found that these actin regulators are required for Osk-dependent formation of long F-actin projections and cortical anchoring of pole plasm components. We propose that, in response to the Osk-mediated endocytic activation, vesicle-localized Mon2 acts as a scaffold that instructs the actin-remodeling complex to form long F-actin projections. This Mon2-mediated coupling event is crucial to restrict the pole plasm to the oocyte posterior cortex.
Expression regulated by
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Ovarian localization Oocyte
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Follicle stages
Comment
Phenotypes
Mutations 0 mutations
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created: June 6, 2011, 12:12 p.m. by: hsueh   email:
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last update: June 6, 2011, 12:12 p.m. by: hsueh    email:



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