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UDP-glucose pyrophosphorylase 1 OKDB#: 4343
 Symbols: UGP1 Species: human
 Synonyms: UGPP1,  Locus: 1q21-q22 in Homo sapiens


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General Comment
General function Enzyme
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Early embryo development
Comment
Expression regulated by
Comment
Ovarian localization Cumulus, Granulosa
Comment Identification of follicular marker genes as pregnancy predictors for human IVF: new evidence for the involvement of luteinisation process. Hamel M et al. Multiple pregnancy represents an important health risk to both mother and child in fertility treatment. To reduce a high twin rate, restriction to one embryo transfer is needed. Morphological evaluation methods for predicting embryo viability has significant limitations. Tight communication exists between the follicular cells (FCs) and the oocyte; therefore, developmental competence may be determined by markers expressed in the surrounding FCs. In this study, cells were recovered on a per-follicle basis by individual follicle puncture. Hybridization analysis using a custom-made complementary DNA microarray containing FC transcripts was performed. Genes expressed in FCs associated with good morphological transferred embryos were identified from follicles associated with a pregnancy outcome (pregnancy group) or no pregnancy (non-pregnancy group). Ten candidates from the Pregnancy group and three from the Non-pregnancy group were validated by qRT-PCR. The best predictors associated with pregnancy were UDP-glucose pyrophosphorylase-2 (UGP2) and pleckstrin homology-like domain, family A, member 1 (PHLDA1). Genes assessment showed no significant candidate genes associated with non-pregnancy outcome, but GA-binding protein transcription factor beta1 (GABPB1) showed a tendency to be potentially more expressed in the non-pregnancy group. These markers could be related to granulosa luteinisation process and could be used to improve embryo selection for successful single embryo transfer.
Follicle stages Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
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created: July 13, 2010, 8:38 p.m. by: hsueh   email:
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last update: July 13, 2010, 8:40 p.m. by: hsueh    email:



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