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Ovarian Kaleidoscope Database (OKdb)



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Hsueh lab


since 01/2001:

Chordin OKDB#: 4271
 Symbols: CHRD Species: human
 Synonyms: MGC133038,  Locus: 3q27 in Homo sapiens

For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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DNA Microarrays
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General Comment NCBI Summary: This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq]
General function Extracellular binding protein
Cellular localization Secreted
Ovarian function
Expression regulated by
Ovarian localization
Comment First Evidence of Bone Morphogenetic Protein 1 Expression and Activity in Sheep Ovarian Follicles. Canty-Laird E et al. Bone morphogenetic protein 1 (BMP1) is a vertebrate metalloproteinase of the astacin family. BMP1 plays a key role in regulating the formation of the extracellular matrix (ECM), particularly by processing the C-propeptide of fibrillar procollagens. BMP1 also promotes BMP signaling by releasing BMP signaling molecules from complexes with the BMP-antagonist chordin. As a result of BMP1's dual role in both ECM formation and BMP signaling, we hypothesized that BMP1 could play a role in ovarian physiology. Using the sheep ovary as a model system, it was shown that BMP1 was expressed in the ovary throughout early fetal stages to adulthood. Furthermore, in adult ovaries, BMP1 was expressed along with chordin, BMP4 and twisted gastrulation, together known to form an extracellular regulatory complex for BMP signaling. Within ovine ovaries, immunohistochemical localization demonstrated that BMP1 was present in granulosa cells at all stages of follicular development, from primordial to large antral follicles and that the levels of BMP1 were not affected by the final follicle selection mechanism. In cultured granulosa cells, BMP1 expression was not affected by gonadotropins, but BMP4 and activin A had opposing effects on the levels of BMP1 mRNA. BMP1 appeared to be secreted into the follicular fluid of antral follicles where it is able to exert procollagen C-proteinase (PCP) and chordinase activities. Interestingly, BMP1 activity in follicular fluid decreased with follicular growth.
Follicle stages
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: April 7, 2010, 11:37 a.m. by: hsueh   email:
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last update: April 7, 2010, 11:38 a.m. by: hsueh    email:

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