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Ovarian Kaleidoscope Database (OKdb)

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tudor domain containing 5 OKDB#: 4260
 Symbols: TDRD5 Species: human
 Synonyms: TUDOR3, FLJ34823, MGC163404, RP11-427G13.1,  Locus: 1q25.2 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: Entrez Gene
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General Comment
General function Cell proliferation, RNA processing
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Primordial Germ Cell
Comment LOTUS, a new domain associated with small RNA pathways in the germline. Callebaut I et al. We describe here LOTUS, a hitherto uncharacterized small globular domain, which was identified using sensitive sequence profile analysis. The LOTUS domain is found in germline specific proteins, which are present in the nuage / polar granules of germ cells. TDRD5 and TDRD7, two mammalian members of the germline Tudor group, possess three copies of the LOTUS domain in their extreme N-termini. The Tudor domains of these proteins bind symmetric di-methyl arginines present on the germ cell-specific Piwi proteins, which form a particular clade of Argonaute proteins. Piwi proteins interact with a specific class of non-coding RNAs (piRNAs or piwiinteracting RNAs) and play a key role in the repression (silencing) of transposons and possibly other germline-specific functions. A LOTUS domain is also present in the Oskar protein, a critical component of the pole plasm in the Drosophila oocyte, which is required for germ cell formation. LOTUS domains are found in various proteins from metazoans and plants, are often associated with RNA-specific modules and are likely to adopt a winged helix fold. This suggests a germline specific role in the mRNA localization and/or translation or a specific function towards piRNAs. CONTACT: isabelle.callebaut@impmc.upmc.fr SUPPLEMENTARY INFORMATION: Supplementary data for this article are available at Bioinformatics on line.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: March 25, 2010, 3:01 p.m. by: hsueh   email:
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last update: March 25, 2010, 3:02 p.m. by: hsueh    email:



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