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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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zinc finger, NFX1-type containing 1 OKDB#: 3886
 Symbols: ZNFX1 Species: human
 Synonyms: FLJ39275, MGC131926,  Locus: 20q13.13 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: Entrez Gene
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DNA Microarrays
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link to BioGPS
General Comment
General function DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Allegro: Analyzing expression and sequence in concert to discover regulatory programs. Halperin Y et al. A major goal of system biology is the characterization of transcription factors and microRNAs (miRNAs) and the transcriptional programs they regulate. We present Allegro, a method for de-novo discovery of cis-regulatory transcriptional programs through joint analysis of genome-wide expression data and promoter or 3' UTR sequences. The algorithm uses a novel log-likelihood-based, non-parametric model to describe the expression pattern shared by a group of co-regulated genes. We show that Allegro is more accurate and sensitive than existing techniques, and can simultaneously analyze multiple expression datasets with more than 100 conditions. We apply Allegro on datasets from several species and report on the transcriptional modules it uncovers. Our analysis reveals a novel motif over-represented in the promoters of genes highly expressed in murine oocytes. The present gene id highly expressed in the oocyte and has a unique promoter motif.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Jan. 25, 2009, 11:31 a.m. by: hsueh   email:
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last update: Jan. 25, 2009, 11:31 a.m. by: hsueh    email:



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