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Metastasis Suppressor 1 OKDB#: 3842
 Symbols: MTSS1 Species: human
 Synonyms: MIM, MIMA, MIMB, FLJ44694, KIAA0429, DKFZp781P2223,MIM|KIAA0429  Locus: 8p22 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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R-L INTERACTIONS   MGI

DNA Microarrays
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link to BioGPS
General Comment
General function Tumor suppressor
Comment
Cellular localization
Comment
Ovarian function Ovulation
Comment
Expression regulated by LH, Eicosanoids
Comment Gene expression profiling of bovine preovulatory follicles: Gonadotropin surge and prostanoid dependent up-regulation of genes potentially linked to the ovulatory process. Li Q et al. The molecular mechanisms of ovulation and luteinization have not been well established, partially due to lack of a comprehensive understanding of functionally significant genes up-regulated in response to an ovulatory stimulus and the signaling pathways involved. In the present study, transcripts increased in bovine preovulatory follicles following a GnRH-induced LH surge were identified using microarray technology. Increased expression of 368 and 878 genes was detected at 12 (368 genes) and 20 h (878 genes) following GnRH injection. The temporal, cell specific and prostanoid dependent regulation of selected genes (ADAM10, DBI, CD36, MTSS1, TFG, and RABGAP1) identified from microarray studies and related genes (ADAM17, AREG) of potential significance were also investigated. Expression of mRNA for DBI and CD36 was simultaneously up-regulated in theca and granulosa cells following the LH surge, whereas temporal regulation of ADAM10, MTSS1, TFG and RABGAP1 was distinct in the two cell compartments and increased granulosa TFG and RABGAP1 mRNA was prostanoid dependent. AREG mRNA was increased in theca and granulosa cells at 12 and 24 h following GnRH injection. ADAM17 mRNA was increased in theca, but reduced in granulosa cells 24 h following GnRH injection. The increased ADAM17 and AREG mRNA was prostanoid dependent. ADAM10 and ADAM17 protein were increased specifically in the apex but not the base of preovulatory follicles and the increase in ADAM17 was prostanoid dependent. Results reveal novel information on regulation of preovulatory gene expression and suggest a potential functional role for ADAM10 and ADAM17 proteins in the region of follicle rupture.
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
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created: Nov. 12, 2008, 1 p.m. by: hsueh   email:
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last update: Nov. 12, 2008, 1:02 p.m. by: hsueh    email:



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