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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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Glypican 3 OKDB#: 3782
 Symbols: GPC3 Species: human
 Synonyms: SGB, DGSX, SDYS, SGBS, OCI-5, SGBS1,  Locus: Xq26.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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link to BioGPS
General Comment NCBI Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.
General function
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Ovarian tumor
Comment Glypican-3 immunohistochemistry in the ovary. Histopathology. 2008 May 6;. [Epub ahead of print] PMID: 18462363 PMID: 20972242
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: May 14, 2008, 1:08 p.m. by: hsueh   email:
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last update: Oct. 27, 2010, 9:38 a.m. by: hsueh    email:



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