| Mitogen-activated Protein Kinase-activated Protein Kinase 5 | OKDB#: 3651 |
| Symbols: | MAPKAPK5 | Species: | human | ||
| Synonyms: | PRAK,MAPKAP KINASE 5|p38-REGULATED/ACTIVATED KINASE, PRAK | Locus: | 12q24.12-q24.13 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Nov. 1, 2006, 5 p.m. | by: |
amazinmazin email:
home page: |
| last update: | Nov. 27, 2006, 12:27 p.m. | by: | hsueh email: |
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