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Ovarian Kaleidoscope Database (OKdb)

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Cytochrome P450, Subfamily I, Polypeptide 2 OKDB#: 3356
 Symbols: CYP1A2 Species: human
 Synonyms: CP12, P3-450, P450(PA),CYTOCHROME P-450, AROMATIC COMPOUND-INDUCIBLE|DIOXIN-INDUCIBLE P3-450|PHENACETIN METABOLISM, DEFECT IN, INCLUDED|PHENACETIN O-DEETHYLASE, DEFICIENCY OF, INCLUDED  Locus: 15q24 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment NCBI Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
General function
Comment
Cellular localization
Comment
Ovarian function Oogenesis, Oocyte maturation
Comment Gene whose expression is detected by cDNA array hybridization: cell surface antigens, cell adhesion, receptors. Also, relative transcript level reproducibly decreases during IVM Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: July 18, 2006, 11:14 a.m. by: alex   email:
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last update: July 26, 2006, 3:05 p.m. by: Alex    email:



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