| Interleukin 3 Receptor, Alpha | OKDB#: 3351 |
| Symbols: | IL3RA | Species: | human | ||
| Synonyms: | IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra, MGC34174,CD123 ANTIGEN, CD123 | Locus: | Xp22.3 or Yp11.3 in Homo sapiens | HPMR |
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Entrez Gene
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| General Comment | NCBI Summary: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. | ||||
| General function | Receptor | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Gene whose expression is detected by cDNA array hybridization: cell surface antigens, cell adhesion, receptors Rozenn Dalbi?Tran and Pascal Mermilloda | ||||
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| Ovarian localization | Oocyte, Granulosa | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | July 18, 2006, 11:07 a.m. | by: |
alex email:
home page: |
| last update: | April 12, 2014, 2:14 p.m. | by: | Hsueh email: |
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