| Ga-binding Protein Transcription Factor, Beta Subunit | OKDB#: 3313 |
| Symbols: | GABPB | Species: | human | ||
| Synonyms: | E4TF1, GABPB, BABPB2, E4TF1B, GABPB1, NRF2B1, NRF2B2, E4TF1-47, E4TF1-53,GA-BINDING PROTEIN TRANSCRIPTION FACTOR, BETA SUBUNIT 1, INCLUDED, GABPB1, INCLUDED|GABP-BETA, INCLUDED|NUCLEAR RESPIRATORY FACTOR 2, BETA SUBUNIT 1, INCLUDED, NRF2B1, INCLUDED|NUCLE | Locus: | 15q21.2 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. | ||||
| General function | Nucleic acid binding, DNA binding, Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | Oogenesis, Oocyte maturation, Early embryo development | ||||
| Comment | Identification of follicular marker genes as pregnancy predictors for human IVF: new evidence for the involvement of luteinisation process. Hamel M et al. Multiple pregnancy represents an important health risk to both mother and child in fertility treatment. To reduce a high twin rate, restriction to one embryo transfer is needed. Morphological evaluation methods for predicting embryo viability has significant limitations. Tight communication exists between the follicular cells (FCs) and the oocyte; therefore, developmental competence may be determined by markers expressed in the surrounding FCs. In this study, cells were recovered on a per-follicle basis by individual follicle puncture. Hybridization analysis using a custom-made complementary DNA microarray containing FC transcripts was performed. Genes expressed in FCs associated with good morphological transferred embryos were identified from follicles associated with a pregnancy outcome (pregnancy group) or no pregnancy (non-pregnancy group). Ten candidates from the Pregnancy group and three from the Non-pregnancy group were validated by qRT-PCR. The best predictors associated with pregnancy were UDP-glucose pyrophosphorylase-2 (UGP2) and pleckstrin homology-like domain, family A, member 1 (PHLDA1). Genes assessment showed no significant candidate genes associated with non-pregnancy outcome, but GA-binding protein transcription factor beta1 (GABPB1) showed a tendency to be potentially more expressed in the non-pregnancy group. These markers could be related to granulosa luteinisation process and could be used to improve embryo selection for successful single embryo transfer. | ||||
| Expression regulated by | |||||
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| Ovarian localization | |||||
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| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 22, 2006, 3:38 p.m. | by: |
alex email:
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| last update: | July 13, 2010, 8:44 p.m. | by: | hsueh email: |
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