| B-cell Lymphoma 6 | OKDB#: 3306 |
| Symbols: | BCL6 | Species: | human | ||
| Synonyms: | BCL5, LAZ3, BCL6A, ZNF51, ZBTB27,ZINC FINGER PROTEIN 51, ZNF51|LYMPHOMA-ASSOCIATED ZINC FINGER GENE ON CHROMOSOME 3, LAZ3|BCL6/H4FM FUSION GENE, INCLUDED|BCL6/IKAROS FUSION GENE, INCLUDED|BCL6/LCP1 FUSION GENE, INCLUDED|BLC6/IL21R FUSION GENE, INCLUDED | Locus: | 3q27 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | NCBI Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene. | ||||
| General function | Nucleic acid binding, DNA binding, Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Gene whose expression is detected by cDNA array hybridization: transcription factors, cell signaling and extracellular communication Rozenn Dalbis-Tran and Pascal Mermilloda | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 22, 2006, 3:32 p.m. | by: |
alex email:
home page: |
| last update: | July 26, 2006, 1:56 p.m. | by: | Alex email: |
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