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Mitogen-activated Protein Kinase Kinase 6 OKDB#: 3241
 Symbols: MAP2K6 Species: human
 Synonyms: MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 6, PRKMK6|MKK6, MAPKK6|MAPK/ERK KINASE 6, MEK6  Locus: 17q24.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment

NCBI Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
General function Enzyme, Transferase
Comment
Cellular localization
Comment
Ovarian function Oogenesis, Oocyte maturation
Comment Genes whose expression is detected by cDNA array hybridization: transporters, signal transduction Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
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created: June 22, 2006, 11:45 a.m. by: alex   email:
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last update: July 25, 2006, 3:50 p.m. by: Alex    email:



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