|
General Comment |
Elevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome. Celik C et al. OBJECTIVE: This study investigates human cartilage glycoprotein-39 (YKL-40) levels in polycystic ovary syndrome (PCOS) and controls, and tests their relationship with metabolic and hormonal parameters. DESIGN: Clinical study carried out in an university hospital in Tekirdag, Turkey PATIENTS: Eighty-five women with PCOS and normal glucose tolerance (NGT) and twenty-five women with PCOS and abnormal glucose tolerance (AGT), diagnosed according to Rotterdam criteria, and fifty-nine healthy women. MEASUREMENTS: YKL-40 levels, fasting hormone levels and metabolic parameters were investigated in all subjects. RESULTS: We showed increased YKL-40 levels in women with PCOS compared to controls. (152.573.96 g/L vs. 98.161.6 g/L, P < .000). YKL significantly correlated with BMI (r= 0.344; P < .000), 2hr glucose (r= 0.193; p=0.012), HOMA-IR (r= 0.268; P< .000), and fasting insulin (r= 0.310; P< .000), but not with waist-hip ratio (r= 0.016, P=0.832), and fasting glucose (r= 0.108; P=0.832). When ROC curve analysis was used to analyze the suitability of YKL-40 to identify glucose intolerance in women with PCOS. Area under curve for YKL-40 was found to be significant (AGT-PCOS: AUC 0.660, P = 0.046). CONCLUSION: Plasma YKL-40 levels increased in patients with PCOS compared to healthy subjects. Moreover, there was a significant difference in YKL-40 levels between AGT-PCOS and NGT-PCOS subjects. Subsequently, we also found that YKL-40 levels above the cut-off point may help the clinician to predict abnormal glucose tolerance in PCOS patients. 2012 Blackwell Publishing Ltd.
NCBI Summary:
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
|