| Cleavage Stimulation Factor, 3-prime Pre-rna, Subunit 2, 64-kd | OKDB#: 3020 |
| Symbols: | CSTF2 | Species: | human | ||
| Synonyms: | CstF-64, | Locus: | Xq22.1 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. | ||||
| General function | Cell proliferation, RNA processing | ||||
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| Cellular localization | Nuclear | ||||
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| Comment | The mRNA Encoding {tau}CstF-64 Is Expressed Ubiquitously in Mouse Tissues. Huber Z, et al . Polyadenylation is a process of endonucleolytic cleavage of the mRNA, followed by addition of up to 250 adenosine residues to the 3' end of the mRNA. Polyadenylation is essential for eukaryotic mRNA expression, and CstF-64 is a subunit of the CstF polyadenylation factor that is required for accurate polyadenylation. We discovered that there are two forms of the CstF-64 protein in mammalian male germ cells, one of which (CstF-64) is expressed in all tissues, the other of which (tauCstF-64) is expressed only in male germ cells and in brain (albeit at significantly lower levels in the brain). Therefore, we were surprised to find that, using reverse transcription-PCR, cDNA cloning, and RNA blot analyses, tauCstF-64 mRNA was expressed at higher levels in brain than in testis. Also, tauCstF-64 mRNA was expressed at lower but detectable levels in all tissues tested, including epididymis, heart, kidney, liver, lung, muscle, ovary, spleen, thymus, and uterus. These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Feb. 15, 2006, 9:34 a.m. | by: |
hsueh email:
home page: |
| last update: | Feb. 15, 2006, 9:36 a.m. | by: | hsueh email: |
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