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N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) OKDB#: 2919
 Symbols: NPL Species: human
 Synonyms: NPL1, c112, C1orf13,  Locus: 1q25 in Homo sapiens


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General Comment
General function Enzyme
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte Wu M, et al . From the human fetal brain cDNA library constructed by our lab, a novel variant cDNA of a human gene was successfully cloned and identified. Because the gene has been named N-acetylneuraminate pyruvate lyase (NPL), accordingly we term our splice variant NPL_v2. The cDNA of NPL_v2 has a full-length open reading frame (ORF) from the nucleotide position 320 to 1225 that encodes a protein comprising 301 amino acids. SMART analysis showed that our hypothetical protein has one dihydrodipicolinate synthase (DHDPS) domain. Phosphorylation analysis of the deduced protein show that there are five phosphorylation sites including three "serine" and two "threonine" at the region that are not found in other splice variant. RT-PCR experiment revealed that our splice variant of the gene is mainly expressed in human placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Sept. 14, 2005, 10:15 a.m. by: hsueh   email:
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last update: Sept. 14, 2005, 10:16 a.m. by: system    email:



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