Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Adaptor-related Protein Complex 2, Beta-1 Subunit OKDB#: 2848
 Symbols: AP2B1 Species: human
 Synonyms: CLATHRIN-ASSOCIATED/ASSEMBLY/ADAPTOR PROTEIN, LARGE, BETA-1, CLAPB1|CLATHRIN ADAPTOR COMPLEX AP2, BETA SUBUNIT|AP2-BETA|ADAPTIN, BETA-2  Locus: 17q11.2-q12 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!
R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment
General function Cytoskeleton
Comment
Cellular localization Cytoskeleton
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment Expression of a novel beta adaptin subunit mRNA splice variant in human testes. Zhang XD, et al . Aim: To identify a novel isoform of adaptin 2 beta subunit (named Ap2beta-NY) and to investigate its relationship with testicular development and spermatogenesis. Methods: Using a human testis cDNA microarray, a clone (Ap2?NY), which was strongly expressed in adult testes but weakly expressed in embryo testes, was sequenced and analyzed. Using polymerase chain reaction (PCR), the tissue distribution and expression time pattern of Ap2beta-NY were determined. Results: Ap2?NY was identified and has been deposited in the GenBank (AY341427). The expression level of Ap2?NY in the adult testis was about 3-fold higher than that in the embryo testis. PCR analysis using multi-tissue cDNA indicated that Ap2beta-NY was highly expressed in the testis, spleen, thymus, prostate, ovary, blood leukocyte and brain, but not in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. In addition, Ap2beta-NY was variably expressed in the testes of patients with spermatogenesis-disturbance and spermatogenesis-arrest but not expressed in those of Sertoli-cell-only syndrome, which implied that, in the testis, Ap2?NY was restrictively expressed in germ cells.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: May 19, 2005, 2:11 p.m. by: hsueh   email:
home page:
last update: May 19, 2005, 2:13 p.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form