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HPMR

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5-@hydroxytryptamine Receptor 1d OKDB#: 2682
 Symbols: HTR1D Species: human
 Synonyms: SEROTONIN 5-HT-1D RECEPTOR|5-@HYDROXYTRYPTAMINE RECEPTOR 1D-ALPHA, HTR1DA|RDC4  Locus: 1p36.3-p34.3 in Homo sapiens
HPMR


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General Comment
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Serotonin localization and its functional significance during mouse preimplantation embryo development. Il'kova G, et al . Serotonin is a neurotransmitter functioning also as a hormone and growth factor. To further investigate the biological role of serotonin during embryo development, we analysed serotonin localization as well as the expression of specific serotonin 5-HT1D receptor mRNA in mouse oocytes and preimplantation embryos. The functional significance of serotonin during the preimplantation period was examined by studying the effects of serotonin on mouse embryo development. Embryo exposure to serotonin (1 microM) highly significantly reduced the mean cell number, whereas lower concentrations of serotonin (0.1 microM and 0.01 microM) had no significant effects on embryo cell numbers. In all serotonin-treated groups a significant increase in the number of embryos with apoptotic and secondary necrotic nuclei was observed. Expression of serotonin 5-HT1D receptor mRNA in mouse oocytes and preimplantation embryos was confirmed by in situ hybridization showing a clearly distinct punctate signal. Immunocytochemistry results revealed the localization of serotonin in oocytes and embryos to the blastocyst stage as diffuse punctate cytoplasmic labelling. It appears that endogenous and/or exogenous serotonin in preimplantation embryos could be involved in complex autocrine/paracrine regulations of embryo development and embryo-maternal interactions.
Follicle stages
Comment
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Phenotypes and GWAS show phenotypes and GWAS
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created: Nov. 25, 2004, 3:01 p.m. by: hsueh   email:
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last update: Sept. 19, 2006, 3:53 p.m. by: amazinmazin    email:



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