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HPMR

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Trk-fused Gene OKDB#: 2534
 Symbols: TFG Species: human
 Synonyms: TRKT3 ONCOGENE, INCLUDED  Locus: 3q11-q12 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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link to BioGPS
General Comment TFG encodes a predicted 400-amino acid protein with a putative N-terminal coiled-coil region. On Northern blots, the 2.2-kb TFG mRNA was expressed in all tissues tested. Greco et al. (1995) stated that a coiled-coil structure and ubiquitous expression are features shared by all NTRK1-activating genes as well as genes that activate other tyrosine kinase protooncogenes.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by LH, Eicosanoids
Comment Gene expression profiling of bovine preovulatory follicles: Gonadotropin surge and prostanoid dependent up-regulation of genes potentially linked to the ovulatory process. Li Q et al. The molecular mechanisms of ovulation and luteinization have not been well established, partially due to lack of a comprehensive understanding of functionally significant genes up-regulated in response to an ovulatory stimulus and the signaling pathways involved. In the present study, transcripts increased in bovine preovulatory follicles following a GnRH-induced LH surge were identified using microarray technology. Increased expression of 368 and 878 genes was detected at 12 (368 genes) and 20 h (878 genes) following GnRH injection. The temporal, cell specific and prostanoid dependent regulation of selected genes (ADAM10, DBI, CD36, MTSS1, TFG, and RABGAP1) identified from microarray studies and related genes (ADAM17, AREG) of potential significance were also investigated. Expression of mRNA for DBI and CD36 was simultaneously up-regulated in theca and granulosa cells following the LH surge, whereas temporal regulation of ADAM10, MTSS1, TFG and RABGAP1 was distinct in the two cell compartments and increased granulosa TFG and RABGAP1 mRNA was prostanoid dependent. AREG mRNA was increased in theca and granulosa cells at 12 and 24 h following GnRH injection. ADAM17 mRNA was increased in theca, but reduced in granulosa cells 24 h following GnRH injection. The increased ADAM17 and AREG mRNA was prostanoid dependent. ADAM10 and ADAM17 protein were increased specifically in the apex but not the base of preovulatory follicles and the increase in ADAM17 was prostanoid dependent. Results reveal novel information on regulation of preovulatory gene expression and suggest a potential functional role for ADAM10 and ADAM17 proteins in the region of follicle rupture.
Ovarian localization
Comment This gene was found through a series of mouse ovary microarray analyese.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
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created: June 30, 2004, 9:01 a.m. by: xin   email:
home page:
last update: Nov. 12, 2008, 1:03 p.m. by: hsueh    email:



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