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Cd59 Antigen P18-20 OKDB#: 2515
 Symbols: CD59 Species: human
 Synonyms: PROTECTIN|HUMAN LEUKOCYTE ANTIGEN MIC11, MIC11|SURFACE ANTIGEN RECOGNIZED BY MONOCLONAL ANTIBODY 16.3A5|CD59 DEFICIENCY, INCLUDED  Locus: 11p13 in Homo sapiens
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General Comment The CD59 antigen recognized by monoclonal antibody MEM-43 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. A close relationship to Ly6 of the mouse has been demonstrated. Antigens encoded by both Ly6 and CD59 genes are important to T-cell and NK-cell function. CD59 is also known as protectin. Its function is to restrict lysis of human erythrocytes and leukocytes by homologous complement

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by LH
Comment
Ovarian localization Granulosa
Comment [P2-252] Involvement of Complement System in the Ovulation. Giyoun Na, Mary C Gieske, CheMyong Ko, Yongbum Koo. Sch of Biotechnology and Biomed Sci, Inje Univ, Gimhae, Republic of Korea; Clin Scis, Univ of Kentucky, Lexington, KY It is well known that the ovulation is an inflammatory-like process, which may involve the activation of complement system. Complement system is composed of various proteins that are sequentially activated by inflammatory signal resulting in the formation of membrane attack complex (MAC), which disrupts various types of cell membranes. At the site of inflammatory reaction, on the other hand, host cells produce regulators of complement systems which inhibit the MAC formation. In order to see whether complement system is involved in the ovulatory process, expression patterns of the membrane bound forms of regulators of complement activation (RCA) were examined in the periovulatory stage ovaries. For this purpose, a rat ovarian gene expression database (rOGED) was used. rOGED provides quantitative temporal mRNA expression profiles of 31,000 genes at ovarian (OVA), granulosa cell (GC), and non-granulosa/oocyte ovarian tissue (NGO) levels at various stages of follicular development (Abstract #852214). Of the three main types of RCAs, rOGED detected the expressions of mRNAs for membrane inhibitor of reactive lysis (CD59) and decay accelerating factor (DAF; CD55), but not membrane co-factor protein (MCP). CD59 mRNA was expressed both in GC and NGO all over the time points examined, with the peak expression at 12 h post treatment hCG. Expression of DAF mRNA was dramatically, yet transiently increased at 6 h post hCG treatment. Ten fold higher expression of DAF mRNA was detected in NGO than in GC at all time points examined. Northern blot analyses have confirmed the tissue- and time-dependent expression patterns of the rOGED data. We further examined the expression patterns of the various components of complement system. Surprisingly, within 6 hours of hCG treatment, two fold increase in mRNA expression was observed in the mRNAs for C1q , C3 and C4 proteins. Interestingly, those components were detected only in the NGO, except C1 that is expressed both in GC and NGO. The ovulatory inflammatory reaction is known to facilitate the process of follicle rupture. The inflammatory reaction, however, may give serious damages to the growing follicles, ovulated follicles and other important ovarian tissues. Present study strongly indicates that complement system may be involved in the ovulatory inflammation and the RCAs are expressed to protect ruptured follicles as well as other parts of the ovarian tissues from the potential attack by the complement system.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: June 22, 2004, 5:17 p.m. by: hsueh   email:
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last update: June 22, 2004, 5:19 p.m. by: system    email:



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