Tsai and McKay (2002) found that when stem cells differentiate, nucleostemin expression decreases rapidly prior to cell cycle exit both in vitro and in vivo. The protein was not found in the differentiated cells of adult tissue, suggesting a role in maintaining stem cell self-renewal.
General function
Comment
Cellular localization
Comment
Ovarian function
Oogenesis
, Pluripotent cell derivation
Comment
Johnson et al reported germline stem cells and follicular renewal in the postnatal mammalian ovary. NUcleostemin was found to be expressed in the ovary.
PMID: 21367294
Reprod Fertil Dev. 2011;23(1):252.
PMID: 21367294