Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Peptidyl-prolyl Isomerase D OKDB#: 2340
 Symbols: PPID Species: human
 Synonyms: CYCLOPHILIN D, CYPD|CYCLOPHILIN 40, CYP40|  Locus: 4q31.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics   Endometrium Database Resource   Orthologous Genes   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!

R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment The cyclophilins are a conserved gene family of peptidyl-prolyl cis-trans isomerases (PPIases; see 123840), the members of which bind the immunosuppressant cyclosporin A. Cyclophilin 40 (CyP-40, also CYPD) was identified by Kieffer et al. (1992) as a 40-kD cyclophilin-like protein with PPIase activity.

General function Cell death/survival, Anti-apoptotic
Comment
Cellular localization Mitochondrial
Comment
Ovarian function Follicle atresia
Comment
Expression regulated by
Comment
Ovarian localization
Comment Cyclophilin d, a component of the permeability transition-pore, is an apoptosis repressor. Schubert A, et al . The permeability transition (PT)-pore is an important proapoptotic protein complex in mitochondria. Although it is activated by many signals for apoptosis induction, the role of its various subunits in cell death induction has remained largely unknown. We found that of its components, only the voltage-dependent anion channel in the outer mitochondrial membrane and the adenine nucleotide translocator-1 (ANT-1), a PT-pore subunit of the inner membrane, are apoptosis inducers. We also report that ANT-1's direct interactor, cyclophilin D, can specifically repress ANT-1-induced apoptosis. In addition, cotransfection experiments revealed that for a diverse range of apoptosis inducers, cyclophilin D shows the same repression profile as the compound bongkrekic acid, a specific inhibitor of the PT-pore. This activity seems to be independent of its chaperone activity, the only known function of cyclophilin D to date. Importantly, cyclophilin D is specifically up-regulated in human tumors of the breast, ovary, and uterus, suggesting that inhibition of the PT-pore via up-regulation of cyclophilin D plays a role in tumorigenesis.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: Jan. 22, 2004, 12:48 p.m. by: hsueh   email:
home page:
last update: Jan. 22, 2004, 12:48 p.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form