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Crystallin, Alpha-a OKDB#: 2236
 Symbols: CRYAA Species: human
 Synonyms: CRYSTALLIN, ALPHA-1, CRYA1|CATARACT, ZONULAR CENTRAL NUCLEAR, INCLUDED|CATARACT, AUTOSOMAL RECESSIVE, CONGENITAL PROGRESSIVE, INCLUDED|  Locus: 21q22.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Cell cycle regulation
Comment
Cellular localization Cytoplasmic, Nuclear
Comment
Ovarian function Luteinization
Comment
Expression regulated by
Comment
Ovarian localization Luteal cells, Stromal cells
Comment Alpha B-crystallin in corpora lutea of pseudopregnant rat Masso R,et al 2003 . Localization sites and labeling intensity of alphaB-crystallin in corpus luteum (CL) of pseudopregnant rats has been studied using postembedding light and electron microscopical immunohistochemistry. At days 2 and 18 alphaB-crystallin labeling was found to be significantly higher compared with the luteal maintenance period (days 6 and 10). alphaB-crystallin localized both to luteal and interstitial cells of CL. At light microscopical level alphaB-crystallin labeling decreased during CL life span in the central area of luteal cells cytoplasm and increased in the peri-plasmalemmal area. Interstitial cells labeling was found to increase at day 6, followed by almost complete disappearance during functional luteolysis (days 15 and 18). Our results at electron microscopical level showed alphaB-crystallin to localize in cytoplasm with close relationship with endoplasmic reticulum, Golgi apparatus, mitochondria and also in nuclei of luteal and interstitial cells. At day 2 labeling of luteal cells was abundant in cytoplasm but weak in nuclei. During the luteal maintenance period and functional luteolysis labeling in luteal cells was relocalized to the peri-plasmalemmal and perinuclear areas. Labeling in nuclei of luteal cells was weak. At the same time (day 6) interstitial cells including nuclei showed strong labeling, which was significantly decreased during luteolysis. Immunohistochemically detectable tubulin decreased in CL tissue during CL life span allowing to suggest that alphaB-crystallin acts as chaperone, one possible role of which is to stabilize the cytoskeleton in different CL cell types during CL formation and active functioning.
Follicle stages Corpus luteum
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Oct. 31, 2003, 9:21 a.m. by: hsueh   email:
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last update: Nov. 8, 2003, 5:39 p.m. by: system    email:



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