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Semaphorin 4d OKDB#: 2226
 Symbols: SEMA4D Species: human
 Synonyms: SEMAPHORIN J, SEMAJ|LEUKOCYTE ACTIVATION ANTIGEN CD100, CD100|COLLAPSIN 4, COLL4|  Locus: 9q22-q31 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Ligand, Cell death/survival, Anti-apoptotic
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle development
Comment Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development. Regev A et al. ABSTRACT: BACKGROUND: Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form, which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor. Plexin receptors are trans-membrane proteins. The sema domain, found in the extracellular region, is common to all plexins, semaphorins, and the scatter factor receptors and is crucial for the biological activity and plexin receptor specificity. Semaphorin-4D/Plexin-B1 binding provides attractive and repulsive cues for the navigation of axonal growth cones, and new studies suggest that this system also plays a role in the regulation of the biological functions of endothelial cells, specifically in the control of angiogenesis. In a previous study, we have demonstrated the expression and possible role of Plexin-B1 in the mouse ovary. The present study was designed to test the hypothesis that Plexin-B1 effects are mediated by Semaphorin-4D. METHODS: In vivo expression and localization of mouse ovarian Sema-4D were tested by immunohisto-chemistry. The role of Sema-4D in follicular development was examined by in vitro growth of preantral follicles in the presence or absence of Semaphorin-4D, with or without neutralizing antibodies against Plexin-B1. Follicular growth and steroid hormone secretion rates were tested. RESULTS: Semaphorin-4D is expressed in the mouse ovary in vivo mostly in the granulosa cells and and its expression is modulated by PMSG and hCG. In the presence of Semaphorin-4D, in-vitro constant growth was observed as indicated by follicular diameter during the culture period and elevated steroid hormone secretion rates compared with control. These effects were abolished after addition of neutralizing antibodies against Plexin-B1. CONCLUSIONS: In the ovarian follicle, the effect of Plexin-B1 is mediated by sema-4D.
Expression regulated by
Comment
Ovarian localization Granulosa
Comment This gene was found in a mouse DNA array analysis of transcripts expressed in mouse preovulatory follicles.
Follicle stages Primary, Secondary
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Oct. 30, 2003, 6:14 p.m. by: xin   email:
home page:
last update: March 28, 2007, 6:43 a.m. by: hsueh    email:



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