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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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cadherin EGF LAG seven-pass G-type receptor 1 OKDB#: 2167
 Symbols: CELSR1 Species: human
 Synonyms: ME2, FMI2, CDHF9, HFMI2, ADGRC1  Locus: 22q13.31 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment This gene was found in a mouse DNA array analysis of transcripts expressed in mouse preovulatory follicles.

NCBI Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
General function Receptor, Cell adhesion molecule
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Increased expression in oocyte DNA microarray
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Oct. 14, 2003, 10:01 a.m. by: xin   email:
home page:
last update: May 7, 2019, 2:46 p.m. by: hsueh    email:



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