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HPMR

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Macrophage Stimulating 1 Receptor, RON OKDB#: 2124
 Symbols: MST1R Species: human
 Synonyms: RON PROTEIN TYROSINE KINASE, RON| MACROPHAGE STIMULATING PROTEIN RECEPTOR, MSP RECEPTOR|  Locus: 3p21.3 in Homo sapiens
HPMR


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General Comment RON gene product is a membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity. Macrophage stimulating protein (MSP; OMIM 142408), also known as hepatocyte growth factor-like protein (HGFL), is structurally related to hepatocyte growth factor. Gaudino et al. (1994) showed that the RON gene is expressed at the cell surface of several epithelial cell types in addition to granulocytes and monocytes. The RON mRNA is translated into a glycosylated precursor that is cleaved into a 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage. The beta chain undergoes tyrosine phosphorylation upon stimulation by MSP.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 1 mutations

Species: mouse
Mutation name: None
type: null mutation
fertility: subfertile
Comment: The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation Hess KA,et al 2003 . To determine the reproductive effects in mice of the deletion of the tyrosine kinase domain of the Ron receptor. Immature mice with deletion of the tyrosine kinase domain of the Ron receptor (TK-/-) at 22-30 days of age and adult black Swiss female mice at 5-6 weeks of age. Hormonal stimulation of immature female TK-/- animals to induce ovulation. Ovulation rates measured by counting the total number of cumulus oocyte complexes in the ampullar region of the murine oviduct after hormonal stimulation. Western blot analysis measured murine ovarian protein levels of endothelial and inducible nitric oxide synthase (iNOS). Immunohistochemical analysis localized iNOS in the developing murine ovarian follicle.Immature TK-/- mice (22-30 days) ovulate significantly fewer cumulus oocyte complexes. Western blot analyses demonstrated increased levels of iNOS before and after ovulation compared with controls. Conversely, endothelial nitric oxide synthase levels were similar and remained constant during corresponding time periods. Immunohistochemical analyses demonstrated a significant increase in iNOS staining throughout the ovary in TK-/- mice with a significant amount of iNOS in granulosa cells surrounding the oocyte when compared with controls. The increased level of nitric oxide in the TK-/- mice is likely due to an elevated level of iNOS, which may contribute to a decrease in the size of the ovaries and ovulation rates of immature TK-/- animals.

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Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Oct. 1, 2003, 11:05 a.m. by: hsueh   email:
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last update: Dec. 15, 2006, 2:31 p.m. by: hsueh    email:



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