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HPMR

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G Protein-coupled Receptor 23 OKDB#: 1802
 Symbols: GPR23 Species: human
 Synonyms: P2Y5-LIKE RECEPTOR|  Locus: Xq13-q21.1 in Homo sapiens
HPMR


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General Comment Noguchi K, et al reported the identification of p2y9/GPR23 as a novel G protein-coupled receptor for Lysophosphatidic acid, structurally distant from the Edg family. Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and pathological actions on many types of cells. LPA has been widely considered to elicit its biological functions through three types of G protein-coupled receptors, Edg (endothelial cell differentiation gene) 2/LPA1/Vzg (ventricular zone gene) 1, Edg4/LPA2 and Edg7/LPA3. The authors identified an orphan G protein-coupled receptor, p2y9/GPR23, as the fourth LPA receptor (LPA4). Membrane fractions of RH7777 cells transiently expressing p2y9/GPR23 displayed a specific binding for 1-oleoyl-LPA with a Kd value of around 45 nM. Competition binding and reporter gene assays showed that p2y9/GPR23 preferred structural analogs of LPA with a rank order of 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. In Chinese hamster ovary cells expressing p2y9/GPR23, 1-oleoyl-LPA induced an increase in [Ca2+]i, and stimulated adenylyl cyclase activity. Quantitative Real time-PCR demonstrated that mRNA of p2y9/GPR23 was significantly abundant in ovary compared to other tissues. Interestingly, p2y9/GPR23 shares only 20-24% amino acid identities with Edg2, Edg4 and Edg7, and phylogenetic analysis also shows that p2y9/GPR23 is far distant from the Edg family. These facts suggest that p2y9/GPR23 has evolved from different ancestor sequences from the Edg family.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: May 8, 2003, 7:24 p.m. by: hsueh   email:
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last update: Nov. 4, 2003, 10:30 a.m. by: system    email:



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