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HPMR

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Tumor Endothelial Marker 5 OKDB#: 1786
 Symbols: GPR124 Species: human
 Synonyms: TEM5,FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911,TEM5  Locus: 8p12 in Homo sapiens
HPMR


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General Comment Using serial analysis of gene expression (SAGE), St Croix et al. (2000) identified partial cDNAs corresponding to several tumor endothelial markers (TEMs) that displayed elevated expression during tumor angiogenesis. Among the genes they identified was TEM5. TEM5 encodes a predicted 7-pass transmembrane protein of 1,331 amino acids. The N-terminal extracellular region contains 4 simple leucine-rich repeats (LRRs), a C-terminal LRR, an immunoglobulin-type domain, a hormone receptor domain, and a putative G protein-coupled receptor (GPCR) proteolysis site domain typical of class II family members and required for endogenous proteolysis. TEM5 is expressed in the corpus luteum.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Luteinization
Comment
Expression regulated by
Comment
Ovarian localization Luteal cells
Comment
Follicle stages Corpus luteum
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: April 23, 2003, 1:11 p.m. by: hsueh   email:
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last update: July 2, 2007, 4:21 p.m. by: rami    email:



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