Btk29A encodes a product with protein tyrosine kinase (EC:2.7.1.112).
Btk29A exerts pleiotropic functions in different developmental contexts in different tissues through the generation of distinct forms of protein products by means of alternative splicing.
Btk29A is essential for head involution during embryogenesis and ring canal development during oogenesis. (Roulier et al., 1998*)
General function
Receptor
Comment
eukaryotic protein kinase , a src homology 2 (SH2) domain , a tyrosine kinase catalytic domain and a tec/Btk domain
Cellular localization
Plasma membrane
Comment
Ovarian function
Oogenesis, ring canal development
Comment
Expression regulated by
Comment
Ovarian localization
Oocyte, nurse cell , ring canal
Comment
Follicle stages
Comment
cyst
Phenotypes
Mutations
1 mutations
Species: D. melanogaster
Mutation name: Btk29Ae482
type: None fertility: embryonic lethal Comment: Females with homozygous germ line clones have defects in ring canal morphogenesis, and show a failure to completely transfer the cytoplasmic contents of the nurse cells to the oocyte. These females produce eggs ranging in size from 50% to 100% of wild-type.
(Guarnieri et al., 1998)