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HPMR

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Protein-tyrosine Phosphatase, Nonreceptor-type 8 OKDB#: 1760
 Symbols: PTPN8 Species: human
 Synonyms: PEST-DOMAIN PHOSPHATASE| PEP|  Locus: 1p13 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein-tyrosine kinases (PTK) and protein-tyrosine phosphatases (PTPase). Oncogenesis can result from an imbalance. There are 2 classes of PTPase molecules: low molecular weight proteins with a single conserved phosphatase domain such as T-cell protein-tyrosine phosphatase (PTPT; 176887), and high molecular weight receptor-linked PTPases with 2 tandemly repeated conserved domains separated by 56 to 57 amino acids. [Shiota M, et al $2003 $12554790] reported that Protein Tyrosine Phosphatase PTP20 Induces Actin Cytoskeleton Reorganization by Dephosphorylating p190 RhoGAP in Rat Ovarian Granulosa Cells Stimulated with Follicle-Stimulating Hormone. The authors identified 25 protein tyrosine phosphatases (PTPs) expressed in rat ovarian granulosa cells.

General function
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment
Follicle stages Antral
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: April 8, 2003, 2:24 p.m. by: hsueh   email:
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last update: April 8, 2003, 2:24 p.m. by: system    email:



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