| ZINC FINGER PROTEIN 147; ZNF147; TRIM 25 | OKDB#: 1736 |
| Symbols: | TRIM25 | Species: | human | ||
| Synonyms: | ESTROGEN-RESPONSIVE FINGER PROTEIN, EFP| | Locus: | 17q23.1 in Homo sapiens |
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| General Comment |
EFP is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma (OMIM 601290), a negative cell cycle regulator that causes G2 arrest. This estrogen-responsive finger protein is induced by estrogen via an estrogen-responsive element (ERE)
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| General function | Cell cycle regulation | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Expression regulated by | Steroids | ||||
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| Ovarian localization | Granulosa | ||||
| Comment | Orimo A, et al identified a human estrogen-responsive gene, efp (estrogen-responsive finger protein), which encodes a putative transcription regulator. They report isolation of mouse Efp cDNA and its structure containing three cysteine-rich domains (RING finger and B1 and B2 boxes), a coiled-coil domain, and a C-terminal domain. High levels of Efp mRNA were detected in uterus, ovary, and placenta by RNase protection assay. By in situ hybridization histochemistry the transcripts of efp were also detected in uterus, mammary gland, ovary, and brain, and the co-localization of Efp and estrogen receptor mRNA was particularly demonstrated in these female organs. Moreover, the level of Efp mRNA in uterus and brain, which are known as target organs for estrogen, was up-regulated in vivo by 17 beta-estradiol. Furthermore, both the Efp and estrogen receptor mRNA were stained in the brain vesicles of 11.5-day embryos by whole mount in situ hybridization. These findings raise the possibility that efp is an estrogen-responsive gene that mediates estrogen action in various target organs.In mouse ovary, only granulosa cells but not thecal cells were well stained by antisense Efp RNA probe (Fig. 3G). | ||||
| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | March 13, 2003, 2:49 p.m. | by: |
hsueh email:
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| last update: | July 19, 2004, 10:07 a.m. | by: | system email: |
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