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SH3 DOMAIN, GRB2-LIKE, 3; SH3GL3 OKDB#: 1731
 Symbols: SH3 DOMAIN, GRB2-LIKE, 3; SH3GL3 Species: human
 Synonyms: ENDOPHILIN A3|  Locus: 15q24 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment The Src homology 3 domain (SH3) is an evolutionarily conserved, 50- to 60-amino acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. The SH3 drives protein-protein interactions through binding to proline-rich ligands.

General function
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Hirayama S, et al reported Receptor-Mediated Chicken Oocyte Growth and Differential Expression of Endophilin Isoforms in Developing Follicles. Molecular characterization of the chicken endophilins I, II, and III revealed that their mammalian counterparts have been highly conserved. All chicken endophilins interact via their SH3 domain with the avian dynamin and synaptojanin homologues, and thus share key functional properties of mammalian endophilins. The genes show different expression patterns : as in mammals, expression in the liver is low to undetectable, and high in the brain; in ovarian follicles harboring oocytes rapidly growing via receptor- mediated endocytosis, levels of endophilins II and III, but not of endophilin I, are high. Immunohistochemical analysis of follicles demonstrated that endophilin II is mainly present in the theca interna, but endophilin III predominates within the oocyte proper. Moreover, in a chicken strain with impaired oocyte growth and absence of egg-laying due to a genetic defect in the receptor for yolk endocytosis, endophilin III is diminished in oocytes, while endophilin III levels in the brain and endophilin II localization to thecal cells are unaltered. Thus, these studies reveal that the endophilins differentially contribute to oocyte endocytosis and development.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: March 4, 2003, 5:43 p.m. by: hsueh   email:
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last update: March 4, 2003, 5:43 p.m. by: system    email:



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